Synthesis of Substituted 2-Decalones from 1-Acetylcyclohexenes and α-Trimethylsilyl α,β-Unsaturated Carbonyl Compounds by Two-Fold Michael Reactions. Synthesis of (+/-)-Khusitone

Article abstract of DOI:10.1246/cl.1988.1793

The kinetic enolates of 1-acetyl cyclohexenes undergo two-fold Michael reaction with α-trimethylsilyl α,β-unsaturated carbonyl compounds to produce 5-substituted 2-decalones.The application of this reaction has enabled a synthesis of (+/-)-khusitone.