A lithiation approach to cordycepin analogues variously substituted at the C-8 position

Article abstract of DOI:10.1002/jhet.5570260133

Several 8-substituted cordycepins were prepared via LDA lithiation of 2',5'-bis-O-(t-butyldimethylsilyl)-cordycepin and successive reactions of its C-8 lithiated species with various types of electrophiles. Wittig reaction of the 8-formyl derivative was a