Synthesis of novel isochromene derivatives by tandem Ugi reaction/ nucleophilic substitution

Article abstract of DOI:10.1055/s-0029-1218553

Unprecedented 3-amino-4-amido-lH-isochromenes have been prepared in three steps from protected ortho-(hydroxymethyl)benzaldehyde, with the introduction of three diversity inputs, through a Ugi reaction followed by intramolecular nucleophilic substitution. Georg Thieme Verlag Stuttgart.