A Very Efficient, Short Synthesis of 6,7,8,8a-Tetrahydropyrrolopyrimidines from Imines via 4-Amino-1-azabutadienes

DOI: 10.1055/s-1989-27213

Source and publish data:

Synthesis p. 230 - 232 (1989)

Update date:2022-08-04

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Authors:

Barluenga, Jose

Tomas, Miguel

Jardon, Jesus

Rubio, Eduardo

Gotor, Vincente

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Article abstract of DOI:10.1055/s-1989-27213

N-Substituted imines are transformed into 6,7,8,8a-tetrahydropyrrolo<1,2-a>pyrimidines by base-catalyzed reaction with a nitrile, followed by treatment with aqueous acid at room temperature.

Full text of DOI:10.1055/s-1989-27213

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Product name:[1-(4-Chloro-phenyl)-eth-(E)-ylidene]-(4,4-diethoxy-butyl)-amine

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