2-(Aminomethyl)chromans That Inhibit Iron-Dependent Lipid Peroxidation and Protect against Central Nervous System Trauma and Ischemia

DOI: 10.1021/jm00101a025

Source and publish data:

Journal of Medicinal Chemistry p. 4464 - 4472 (1992)

Update date:2022-08-05

Topics:

Authors:

Jacobsen, E. Jon

VanDoornik, Fred J.

Ayer, Donald E.

Belonga, Kenneth L.

Braughler, J. Mark

et al. et al.

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Article abstract of DOI:10.1021/jm00101a025

A series of 2-(aminomethyl)chromans was developed as potent inhibitors of iron-dependent lipid peroxidation.Compounds within this class are extremely effective at inhibiting lipid peroxidation with IC50's as low as 0.2 μM.Selected members were found to en

Full text of DOI:10.1021/jm00101a025

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