Journal of the American Chemical Society
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The Supporting Information is available free of charge on the
ACS Publications website at DOI:
Experimental procedures, additional reaction optimizaꢀ
tion, and characterization data (PDF)
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(15) (a) Fey, N.; Harvey, J. N.; LloydꢀJones, G. C.; Murray, P.; Orpen,
AUTHOR INFORMATION
A. G.; Osborne, R.; Purdie, M. Organometallics 2008, 27, 1372. (b) Jover,
J.; Fey, N.; Harvey, J. N.; LloydꢀJones, G. C.; Orpen, A. G.; OwenꢀSmith,
G. J. J.; Murray, P.; Hose, D. R. J.; Osborne, R.; Purdie, M. Organometalꢀ
lics 2012, 31, 5302. (c) Jover, J.; Fey, N. Dalton Trans. 2013, 42, 172.
(16) Regression analyses using the available descriptors consistently
yielded models containing nonꢀadditive interaction terms, which compliꢀ
cates both mechanistic interpretation and further experimental validation.
(17) Allen, D. W.; Nowell, I. W.; Taylor, B. F. J. Chem. Soc., Dalton
Trans. 1985, 2505.
Corresponding Authors
ORCID
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Kian L. Tan: 0000ꢀ0001ꢀ8243ꢀ1223
Matthew S. Sigman: 0000ꢀ0002ꢀ5746ꢀ8830
Mitchell H. Keylor: 0000ꢀ0002ꢀ9842ꢀ7234
Notes: The authors declare no competing financial interests.
(18) Solid Cone angles and G parameters were measured with SolidꢀG.
The G parameters directly correlated to the percent buried volume (%VBur
)
measured with SambVca 2.0 [ref. 19b].
(19) (a) Hillier, A. C.; Sommer, W. J.; Yong, B. S.; Petersen, J. L.;
Cavallo, L.; Nolan, S. P. Organometallics 2003, 22, 4322. (b) Falivene,
L.; Credendino, R.; Poater, A.; Petta, A.; Serra, L.; Oliva, R.; Scarano, V.;
Cavallo, L. Organometallics, 2016, 35, 2286.
(20) Fleming, J. T.; Wills, C.; Waddell, P. G.; Harrington, R. W.;
Higham, L. J. Dalton Trans. 2016, 45, 15660.
(21) (a) Moloy, K. G.; Petersen, J. L. J. Am. Chem. Soc. 1995, 117, 7696.
(b) Clarke, M. L.; ColeꢀHamilton, D. J.; Slawin, A. M. Z.; Woollins, J. D.
Chem. Commun. 2000, 2065.
(22) Dyer, P. W.; Fawcett, J.; Hanton, M. J.; Kemmitt, R. D. W.; Padda,
R.; Singh, N. Dalton Trans. 2003, 104.
ACKNOWLEDGMENTS
This work was supported by the Novartis Institutes for Biomediꢀ
cal Research (M.H.K.) and the NSF (Z.L.N. and M.S.S., CHEꢀ
1361296). The support and resources from the Center for High
Performance Computing at the University of Utah are gratefully
acknowledged. The authors thank Jinhai Gao for assistance with
NMR structural determinations.
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