Synthesis of Dinucleotides Containing a Bridged Non-Chiral Internucleotide 5'- or 3'-Phosphoramidate Linkage

Article abstract of DOI:10.1016/S0040-4020(01)81755-5

The synthesis of several dinucleoside phosphate derivatives which are liked by phosphoramidate bonds <3'-O-P(=O)(O^-)-NH-5' or 3'-NH-P(=O)(O^-)-O-5'> has been accomplished.The internucleoside phosphoramidate likage was performed using