New Anticancer Agents: Chiral Isomers of Ethyl 5-Amino-1,2-dihydro-2-methyl-3-phenylpyridopyrazine-7-carbamate

Article abstract of DOI:10.1021/jm00129a012

Racemic ethyl 5-amino-1,2-dihydro-2-methyl-3-phenylpyrido<3,4-b>pyrazine-7-carbamate (1a) has shown antitumor activity in a variety of in vivo experiments.The preparation of the R (9) and S (10) isomers gave compounds with significant differences in potency in several biological tests.