New Anticancer Agents: Chiral Isomers of Ethyl 5-Amino-1,2-dihydro-2-methyl-3-phenylpyridopyrazine-7-carbamate

DOI: 10.1021/jm00129a012

Source and publish data:

Journal of Medicinal Chemistry p. 2089 - 2092 (1989)

Update date:2022-09-26

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Authors:

Temple, Carroll

Rener, Gregory

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Article abstract of DOI:10.1021/jm00129a012

Racemic ethyl 5-amino-1,2-dihydro-2-methyl-3-phenylpyrido<3,4-b>pyrazine-7-carbamate (1a) has shown antitumor activity in a variety of in vivo experiments.The preparation of the R (9) and S (10) isomers gave compounds with significant differences in potency in several biological tests.

Full text of DOI:10.1021/jm00129a012

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