10.1002/ejoc.202000411
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In summary, we have successfully realized the complementary
Cp*IrIII-catalyzed [4+2] annulation reaction of β-keto sulfoxonium
ylides and 1,2-diaminoarene. The advantages of this reaction
containing broad substrates scope, wide functional group
tolerance, mild reaction conditions and compatibility for late-stage
modification. Optimization of the reaction condition indicated that
(Cp*IrCl2)2 is crucial for this transformation. Futhermore, this
reaction provides a new method to the synthesis of quinoxaline.
Efforts to expand the utility of this coupling and to design other
Cp*IrIII-catalyzed cyclization reactions with β-keto sulfoxonium
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This work was supported by a Start-up Grant from Guangdong
Pharmaceutical University (Grant No. 51377002), and the
Guangzhou key laboratory of construction and application of new
drug screening model systems (Grant No.201805010006), and
the key laboratory of new drug discovery and evaluation of
ordinary universities of Guangdong province (Grant No.
2017KSYS002), and Youth Innovation Talents Project of Colleges
and Universities in Guangdong Province (Grant No. 51377201,
51340208), and the Natural Science Foundation of Hunan
Province (Grant No. 12019JJ60071).
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Keywords: sulfoxonium ylides; quinoxaline; iridium-catalyzed;
[4+2] annulation; 1,2-diaminoarene
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