
Chemistry of Heterocyclic Compounds p. 1370 - 1378 (2009)
Update date:2022-08-04
Topics:
Ajani, Olayinka O.
Obafemi, Craig A.
Ikpo, Chinwe O.
Ogunniran, Kehinde O.
Nwinyi, Obinna C.
3-Hydrazinoquinoxalin-2(1H)-one was prepared from quinoxaline-2,3-dione and subsequently used for the synthesis of some potentially biologically active 3-(pyrazol-1-yl)quinoxalin-2(1H)-one derivatives. While 3-(3,5-dimethylpyrazol- 1-yl)quinoxalin-2(1H)-one showed a comparative effect with streptomycin, 3-(5-oxo-3-phenyl-4,5-di- hydropyrazol-1-yl)quinoxalin-2(1H)-one was found to be the most active with an MIC value of 7.8 μg/ml.
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