A New Synthetic Route to the Key Precursor of 1β-Methylcarbapenem Antibiotics from (S)-Methyl 3-Hydroxy-2-methylpropanoate

DOI: 10.1246/cl.1989.445

Source and publish data:

Chemistry Letters p. 445 - 448 (1989)

Update date:2022-09-26

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Authors:

Shirai, Fumiyuki

Nakai, Takeshi

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Article abstract of DOI:10.1246/cl.1989.445

A new synthetic route to the 1β-methylcarbapenem precursor from (S)-methyl 3-hydroxy-2-methylpropanoate has been developed which involves as a key step the chelation-controlled aldol reaction of (S)-3-benzyloxy-2-methylpropanal with ketene trimethylsilyl acetal of ethyl (trimethylsilyl)acetate.

Full text of DOI:10.1246/cl.1989.445

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