A New Synthetic Route to the Key Precursor of 1β-Methylcarbapenem Antibiotics from (S)-Methyl 3-Hydroxy-2-methylpropanoate

Article abstract of DOI:10.1246/cl.1989.445

A new synthetic route to the 1β-methylcarbapenem precursor from (S)-methyl 3-hydroxy-2-methylpropanoate has been developed which involves as a key step the chelation-controlled aldol reaction of (S)-3-benzyloxy-2-methylpropanal with ketene trimethylsilyl acetal of ethyl (trimethylsilyl)acetate.