Renin inhibitors based on dipeptide analogues. Incorporation of the hydroxyethylene isostere at the P2/P3 sites

Article abstract of DOI:10.1021/jm00163a059

The synthesis of a series of renin inhibitors in which the P₂ and P₃ amino acids are replaced with the hydroxyethylene dipeptide isostere is reported. In vitro evaluation of the inhibitors has revealed that this isostere is an accept