IMPROVED SYNTHESES OF TWO 3-DEOXYALD-2-ULOSONIC ACIDS(KDN,KDO) BY CONDENSATION OF OXALACETIC ACID WITH ALDOSES FOLLOWED BY Ni2+CATALYZED DECARBOXYLATION

DOI: 10.1016/S0040-4039(00)99665-5

Source and publish data:

Tetrahedron Letters p. 2263 - 2264 (1989)

Update date:2022-08-03

Topics:

Authors:

Shirai, Ryuichi

Ogura, Haruo

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Article abstract of DOI:10.1016/S0040-4039(00)99665-5

Condensation of oxalacetic acid with D-mannose and D-arabinose followed by Ni²⁺catalyzed decarboxylation gave 3-deoxy-D-glycero-D-galacto-2-nonulosonic acid(KDN) and 3-deoxy-D-manno-2-octulosonic acid(KDO) respectively in high chemical yield and high diastereoselectivity.

Full text of DOI:10.1016/S0040-4039(00)99665-5

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