Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl]amino]-b benzoyl]-L-glutamic acid

DOI: 10.1021/jm00164a014

Source and publish data:

Journal of Medicinal Chemistry p. 561 - 567 (1990)

Update date:2022-08-05

Topics:

Authors:

Kelley Kelley

McLean McLean

Cohn Cohn

Edelstein

Duch Duch

Smith Smith

Hanlon Hanlon

Ferone Ferone

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00164a014

The synthesis and biological evaluation of N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl) propyl]amino]-benzoyl]-L-glutamic acid (1) (5-DACTHF, 543U76), an acyclic analogue of 5,6,7,8-tetrahydrofolic acid (TFHA), are described. The key intermediat

Full text of DOI:10.1021/jm00164a014

Products guided by the article

Product name:2,6-bis(acetylamino)-5-(3-anilinopropyl)-4(3H)-pyrimidinone

Cas No:123541-74-2

R&D Labs maybe for 123541-74-2

Chuzhou Baiao Biologhy S&T Co., Ltd.

Contact:+86-25-83212599；+86-25-83212699 13705185959

Address:Room 905, Tianzheng International Platza, No.399, Zhongyang Road ,Nanjing, Jiangsu Province, China
Hangzhou Donglou Bio-nutrient Co., Ltd.

Contact:+86-571-82225795,13967112289

Address:Louta Town, Xiaoshan,Hangzhou,Zhejiang
Landz International Company Ltd.

Contact:0086-21-58891610

Address:985 Dongfang Road, Pudong, Shanghai 200122 China
shanghai Tauto Biotech Co., Ltd

website:http://www.tautobiotech.com/en/index.htm

Contact:+86-21-51320588 ext. 8025

Address:No. 326, Aidisheng Rd , Zhangjiang Hi-tech Park, Shanghai , P.R.CHINA
TAIZHOU XINGCHENG CHEMPHARM CO.,LTD.

Contact:0086-0576-88551200,88886292 ,88880039

Address:B Area. 10 Floor.Yaodadasha. 289#.Shifu Road.Taizhou.Zhejiang.China

Relevant to this article

Synthesis and biological activity of N-aroyl-tetrahydro-γ-carbolines

Doi:10.1016/j.bmc.2010.04.034
(2010)
Evaluation of 3-(4′-(4″-fluorophenyl)-6′-phenylpyrimidin- 2′-yl)-2-phenylthiazolidin-4-one for in vivo modulation of biomarkers of chemoprevention in the 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis

Doi:10.3109/14756366.2010.525507
(2011)
Novel synthesis of the isoflavone genistein

Doi:10.1055/s-0029-1219757
(2010)
Organocatalyst in Direct C(_sp²)-H Arylation of Unactivated Arenes: [1-(2-Hydroxyethyl)-piperazine]-Catalyzed Inter-/Intra-molecular C-H Bond Activation

Doi:10.1021/acs.joc.0c01019
(2020)
Defining the key pharmacophore elements of PF-04620110: Discovery of a potent, orally-active, neutral DGAT-1 inhibitor

Doi:10.1016/j.bmc.2013.06.045
(2013)
Infrared spectra of XCIrX₃ and CX₂IrX₂ prepared by reactions of laser-ablated iridium atoms with halomethanes

Doi:10.1039/c002347g
(2010)

Article Doi