Journal of Medicinal Chemistry p. 561 - 567 (1990)
Update date:2022-08-05
Topics:
Kelley
McLean
Cohn
Edelstein
Duch
Smith
Hanlon
Ferone
The synthesis and biological evaluation of N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl) propyl]amino]-benzoyl]-L-glutamic acid (1) (5-DACTHF, 543U76), an acyclic analogue of 5,6,7,8-tetrahydrofolic acid (TFHA), are described. The key intermediat
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