Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl]amino]-b benzoyl]-L-glutamic acid

DOI: 10.1021/jm00164a014

Source and publish data:

Journal of Medicinal Chemistry p. 561 - 567 (1990)

Update date:2022-08-05

Topics:

Authors:

Kelley Kelley

McLean McLean

Cohn Cohn

Edelstein

Duch Duch

Smith Smith

Hanlon Hanlon

Ferone Ferone

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Article abstract of DOI:10.1021/jm00164a014

The synthesis and biological evaluation of N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl) propyl]amino]-benzoyl]-L-glutamic acid (1) (5-DACTHF, 543U76), an acyclic analogue of 5,6,7,8-tetrahydrofolic acid (TFHA), are described. The key intermediat

Full text of DOI:10.1021/jm00164a014

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