Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl]amino]-b benzoyl]-L-glutamic acid

DOI: 10.1021/jm00164a014

Source and publish data:

Journal of Medicinal Chemistry p. 561 - 567 (1990)

Update date:2022-08-05

Topics:

Authors:

Kelley Kelley

McLean McLean

Cohn Cohn

Edelstein

Duch Duch

Smith Smith

Hanlon Hanlon

Ferone Ferone

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00164a014

The synthesis and biological evaluation of N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl) propyl]amino]-benzoyl]-L-glutamic acid (1) (5-DACTHF, 543U76), an acyclic analogue of 5,6,7,8-tetrahydrofolic acid (TFHA), are described. The key intermediat

Full text of DOI:10.1021/jm00164a014

Products guided by the article

Product name:2,6-bis(acetylamino)-5-(3-anilinopropyl)-4(3H)-pyrimidinone

Cas No:123541-74-2

R&D Labs maybe for 123541-74-2

Haitong Chemical Industrial Co.,Ltd.

website:https://www.haitonglongwin.com/

Contact:+86-022-66221018

Address:18-701, No.99, The 4th Street, TEDA,
Taizhou Shengxing Chempharm Co.,Ltd

Contact:+86-576-88516600

Address:Yantou Chemical Zone Jiaojiang Taizhou Zhejiang China
xujianqiang

Contact:86-21-57725962

Address:shanghai
Shanghai SMEC Trading Co., Ltd.

website:http://www.shanghaismec.com

Contact:+86-21-68811293

Address:ROOM 1101,NO.800 SHANGCHENG RD,SHANGHAI,CHINA
Zhejiang Kangfeng Chemical Co.,LTD.

Contact:+86-579-86709687

Address:Xueshizhai Industrial Zone, Weishan Town,Dongyang City, Zhejiang Province ,China

Relevant to this article

Synthesis and biological activity of N-aroyl-tetrahydro-γ-carbolines

Doi:10.1016/j.bmc.2010.04.034
(2010)
Evaluation of 3-(4′-(4″-fluorophenyl)-6′-phenylpyrimidin- 2′-yl)-2-phenylthiazolidin-4-one for in vivo modulation of biomarkers of chemoprevention in the 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis

Doi:10.3109/14756366.2010.525507
(2011)
Novel synthesis of the isoflavone genistein

Doi:10.1055/s-0029-1219757
(2010)
Organocatalyst in Direct C(_sp²)-H Arylation of Unactivated Arenes: [1-(2-Hydroxyethyl)-piperazine]-Catalyzed Inter-/Intra-molecular C-H Bond Activation

Doi:10.1021/acs.joc.0c01019
(2020)
Defining the key pharmacophore elements of PF-04620110: Discovery of a potent, orally-active, neutral DGAT-1 inhibitor

Doi:10.1016/j.bmc.2013.06.045
(2013)
Infrared spectra of XCIrX₃ and CX₂IrX₂ prepared by reactions of laser-ablated iridium atoms with halomethanes

Doi:10.1039/c002347g
(2010)

Article Doi