Erratum: Synthesis of novel MMT/acyl-protected nucleo alanine monomers for the preparation of DNA/alanyl-PNA chimeras (Amino Acids DOI: 10.1007/s00726-009-0324-x)

Full text of DOI:10.1007/s00726-009-0455-0

Amino Acids (2010) 38:1311–1312
DOI 10.1007/s00726-009-0455-0
ERRATUM
Erratum to: Synthesis of novel MMT/acyl-protected nucleo
alanine monomers for the preparation of DNA/alanyl-PNA
chimeras
•
G. N. Roviello S. Groschel C. Pedone
•
•
¨
U. Diederichsen
Published online: 21 April 2010
Ó Springer-Verlag 2010
Erratum to: Amino Acids
DOI 10.1007/s00726-009-0324-x
Scheme 1 was incorrect and is reproduced correctly here.
The online version of the original article can be found under
doi:10.1007/s00726-009-0324-x.
¨
G. N. Roviello Á S. Groschel Á U. Diederichsen (&)
Institut fu¨r Organische und Biomolekulare Chemie,
¨
Georg-August-Universitat Gottingen, Tammannstr. 2,
37077 Gottingen, Germany
¨
¨
e-mail: udieder@gwdg.de
G. N. Roviello Á C. Pedone
Istituto di Biostrutture e Bioimmagini-CNR,
Via Mezzocannone 16, 80134 Naples, Italy
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G. N. Roviello et al.
Scheme 1 Synthesis of
Boc- and MMT-protected
nucleo amino acids with acyl
protected nucleobases
O
N
1. TFA, 1h
2. MMTCl, NEt3,
DMF
HN
N
N
N
OMe
2
67 %
BocHN
OMe
CO2H
O
7
HN
N
DBU, DMSO,
rt, 32 %
N
1
N
H
N
8
1. TFA, 1h
41 %
2. MMTCl, NEt3,
DMF
O
O
N
1.
H3C
H
NH
O
O
N
H
N
O
N
H
N
N
N
NH
O
N
H
O
O
O
H
12
BocHN
O
N
N
N
N
H
CH3
5
DBU, DMSO
rt, 31 %
DBU, DMSO
rt, 57 %
BocHN
CO2H
BocNH
CO2H
11
6
O
HN
1. TFA, 2h
DBU, DMSO,
rt, 42 %
31 % 2. MMTCl, NEt3,
DMF
N
tBu
N
O
N
9
tBu
4
H
1. TFA, 2h
2. MMTCl, NEt3,
H
N
O
DMF
3
O
N
25 %
BocHN
CO2H
10
123