Journal of Medicinal Chemistry p. 281 - 286 (1990)
Update date:2022-08-05
Topics:
Ringdahl, Bjoern
Mellin, Charlotta
Ehlert, Frederick J.
Roch, Margareth
Rice, Kathleen M.
Jenden, Donald J.
4-<(2-Chloroethyl)methylamino>-2-butynyl N-(3-chlorophenyl)carbamate (2) and 4-<(2-bromoethyl)methylamino>-2-butynyl N-(3-chlorophenyl)carbamate (3) were synthesized.Compounds 2 and 3 cyclized at neutral pH to an aziridinium ion (4).The rate constants for
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