Archiv der Pharmazie p. 573 - 578 (1989)
Update date:2022-09-26
Topics:
Meise, Werner
Mika, Ulrike
The aminolysis of cis-hexahydroisochromane-2-one (cis-2) with the 2-phenylethylamines 1 can be regulated in such a way that mainly the cis- or mainly the trans-δ-hydroxyamides 3 result.These compounds react with SOCl2 to the corresponding isochromane-1-imines 4 (not isolable in our case), the structure of which is proofed by hydrolysis to 1 and 2, as well as by preparative reaction to the δ-chloroamides 5 and by reduction to the δ-aminoalcoholes 6.All reactions of 3 and of 4 proceed with retention of the configuration.
View MoreShanghai Yingrui Biopharma Co., Ltd
Contact:021-3358 8661*8003
Address:shanghai
SHENZHEN PENGCHENG REDSTAR INDUSTRY CO.,LTD
Contact:+86-755-82412922
Address:Room 8066, East Block, Square City, Jiabin Road, Luohu District
Zhengzhou Xinlian Chemical Tech Co. ,Ltd
Contact:0371-65771781 021-52042910
Address:H Part, Building I, No. 700 Gonglu Road, Pudong New Area, Shanghai
Shenzhen Feiming Science and Technology Co,. Ltd
Contact:+86-755-85232577
Address:#B2309, Fenglin International Center ,Jixiang Road, Longcheng street, LongGang District, Shenzhen city, Guangdong province, China.
Shanghai Dynamic Industrial Co.,Ltd.
website:http://www.shdynamic.com
Contact:86-021 3392 6680
Address:Room 805 Information Tower, No.1403 Minsheng Road, Pudong New Area, Shanghai 200135, P. R. China
Doi:10.1021/ol101720e
(2010)Doi:10.1002/ejoc.201000051
(2010)Doi:10.1002/ejoc.201000365
(2010)Doi:10.1055/s-0029-1218804
(2010)Doi:10.1021/acsmedchemlett.8b00645
(2019)Doi:10.1021/ol1015898
(2010)
