ACS Medicinal Chemistry Letters
Letter
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significantly less active against the H3N2 virus VR1979.
Totarol, however, likely has a broader spectrum of anti-IAV
activity. Therefore, totarol is a promising new scaffold for the
synthesis of anti-IAV agents with increased potency and
breadth of anti-IAV activity.
ASSOCIATED CONTENT
* Supporting Information
■
S
Experimental procedures for biological assays, synthesis, and
analytical data. This material is available free of charge via the
AUTHOR INFORMATION
Corresponding Authors
■
Funding
This work was supported by NIH/NIAID Grants AI108347 (to
L.H.) and AI65310 (to C.H.C.).
Notes
The authors declare no competing financial interest.
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ABBREVIATIONS
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IAV, influenza A virus; NP, nucleoprotein; HA, hemagglutinin;
NA, neuraminidase; DAPI, diamidino-2-phenylindole; PA,
podocarpic acid
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