Synthesis of lasofoxifene, nafoxidine and their positional isomers via the novel three-component coupling reaction

Article abstract of DOI:10.3390/molecules15106773

A Lewis acid-mediated three-component coupling reaction was successfully applied for the synthesis of lasofoxifene (1), nafoxidine (2), and their positional isomers, inv-lasofoxifene (3) and inv-nafoxidine (4). In the presence of HfCl₄, the des