CLEAVAGE OF A NUCLEOSIDIC OXETANE WITH CARBANIONS: SYNTHESIS OF A HIGHLY PROMISING CANDIDATE FOR ANTI-HIV AGENTS - A PHOSPHONATE ISOSTERE OF AZT 5'-PHOSPHATE

DOI: 10.1016/S0040-4039(01)80452-4

Source and publish data:

Tetrahedron Letters p. 2567 - 2570 (1989)

Update date:2022-07-29

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Authors:

Tanaka, Hiromichi

Fukui, Mariko

Haraguchi, Kazuhiro

Masaki, Mariko

Miyasaka, Tadashi

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Article abstract of DOI:10.1016/S0040-4039(01)80452-4

A phosphonate analogue of 3'-azido-3'-deoxythymidine (AZT) 5'-phosphate was synthesized via nucleophilic ring-opening of a nucleosidic oxetane with (RO)2POCH2Li as a key reaction step.

Full text of DOI:10.1016/S0040-4039(01)80452-4

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