CLEAVAGE OF A NUCLEOSIDIC OXETANE WITH CARBANIONS: SYNTHESIS OF A HIGHLY PROMISING CANDIDATE FOR ANTI-HIV AGENTS - A PHOSPHONATE ISOSTERE OF AZT 5'-PHOSPHATE

DOI: 10.1016/S0040-4039(01)80452-4

Source and publish data:

Tetrahedron Letters p. 2567 - 2570 (1989)

Update date:2022-07-29

Topics:

Authors:

Tanaka, Hiromichi

Fukui, Mariko

Haraguchi, Kazuhiro

Masaki, Mariko

Miyasaka, Tadashi

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(01)80452-4

A phosphonate analogue of 3'-azido-3'-deoxythymidine (AZT) 5'-phosphate was synthesized via nucleophilic ring-opening of a nucleosidic oxetane with (RO)2POCH2Li as a key reaction step.

Full text of DOI:10.1016/S0040-4039(01)80452-4

Products guided by the article

Product name:1-[(2R,4R,5R)-5-(2,2-Dimethyl-propyl)-4-hydroxy-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

Cas No:124685-31-0

R&D Labs maybe for 124685-31-0

Shanghai Hohance Chemical Co., ltd

Contact:13914753421

Address:Fl.5；Bld. 70, Lane 1500; Xinfei Road
GIHI CHEMICALS CO.,LIMITED

Contact:+86-571-86217390

Address:No.567 Dengcai Street,Sandun,Westlake District,Hangzhou310030,Zhejiang,China.
Nantong Auxin Electronic Technology Co., LTD

Contact:86-513-88760026

Address:NO.5-1, Aoxin Road, Haian Hi-tech Development Zone, Jiangsu Province, China
Mollt Biochem Co., Ltd(expird)

Contact:+86-21-38682181

Address:shanghai ,china
HENAN NEW BLUE CHEMICAL CO.,LTD

website:http://www.newbluechem.com

Contact:86-371-55170693/55170694

Address:Zhengzhou International Trade New Territory,Jinshui District,Zhengzhou ,China

Relevant to this article

One-pot synthesis of polyfunctionalized 4H-pyran derivatives bearing fluorochloro pyridyl moiety

Doi:10.1016/j.tetlet.2010.07.065
(2010)
Synthetic studies of mycalolide B, an actin-depolymerizing marine macrolide: Construction of the tris-oxazole macrolactone using ring-closing metathesis

Doi:10.1016/j.tetlet.2010.07.046
(2010)
Comparative studies of bile salts. VI. Partial synthesis of coprostanic acid, a stem acid of primitive bile salts.

Doi:10.1042/bj0520588
(1952)
An efficient synthesis of functionalized 2-pyridones by direct route or via amide/enolate ammonium salt intermediates

Doi:10.1055/s-1999-3531
(1999)
6-(1-benzyl-1 h -pyrrol-2-yl)-2,4-dioxo-5-hexenoic acids as dual inhibitors of recombinant HIV-1 integrase and ribonuclease H, synthesized by a parallel synthesis approach

Doi:10.1021/jm401040b
(2013)
The modification of ArSCH₂(3,5-Me₂Pz) (Ar = phenyl or 2-pyridyl, Pz = pyrazol-1-yl) by organotin group and related reactions

Doi:10.1016/j.jorganchem.2010.06.006
(2010)

Article Doi