CLEAVAGE OF A NUCLEOSIDIC OXETANE WITH CARBANIONS: SYNTHESIS OF A HIGHLY PROMISING CANDIDATE FOR ANTI-HIV AGENTS - A PHOSPHONATE ISOSTERE OF AZT 5'-PHOSPHATE

DOI: 10.1016/S0040-4039(01)80452-4

Source and publish data:

Tetrahedron Letters p. 2567 - 2570 (1989)

Update date:2022-07-29

Topics:

Authors:

Tanaka, Hiromichi

Fukui, Mariko

Haraguchi, Kazuhiro

Masaki, Mariko

Miyasaka, Tadashi

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(01)80452-4

A phosphonate analogue of 3'-azido-3'-deoxythymidine (AZT) 5'-phosphate was synthesized via nucleophilic ring-opening of a nucleosidic oxetane with (RO)2POCH2Li as a key reaction step.

Full text of DOI:10.1016/S0040-4039(01)80452-4

Products guided by the article

Product name:1-[(2R,4R,5R)-5-(2,2-Dimethyl-propyl)-4-hydroxy-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

Cas No:124685-31-0

R&D Labs maybe for 124685-31-0

N&R INDUSTRIES,INC

Contact:Tel:+86-29-88764861 Fax:+86-29-88764861

Address:Rm#2107, Block A, Epin Meidao Building, Gaoxin Rd, Hi-Tech Zone, Xi’an, China
Shaanxi King Stone Enterprise Company Limited

Contact:86-29-88353805,13609285751

Address:.209 Keji Road Hi-Tech industrial Develpment Zone .Xian China
Dragon Chemical Co., Ltd.

Contact:0571-

Address:zhejing
Puyang Willing Chemicals Co.,Ltd.

Contact:86-393-4840366

Address:Puyang Henan China
Suzhou JMS Chemical Co., Ltd.

Contact:+86-15995924277

Address:WuZhongOu suzhou new south road 89

Relevant to this article

One-pot synthesis of polyfunctionalized 4H-pyran derivatives bearing fluorochloro pyridyl moiety

Doi:10.1016/j.tetlet.2010.07.065
(2010)
Synthetic studies of mycalolide B, an actin-depolymerizing marine macrolide: Construction of the tris-oxazole macrolactone using ring-closing metathesis

Doi:10.1016/j.tetlet.2010.07.046
(2010)
Comparative studies of bile salts. VI. Partial synthesis of coprostanic acid, a stem acid of primitive bile salts.

Doi:10.1042/bj0520588
(1952)
An efficient synthesis of functionalized 2-pyridones by direct route or via amide/enolate ammonium salt intermediates

Doi:10.1055/s-1999-3531
(1999)
6-(1-benzyl-1 h -pyrrol-2-yl)-2,4-dioxo-5-hexenoic acids as dual inhibitors of recombinant HIV-1 integrase and ribonuclease H, synthesized by a parallel synthesis approach

Doi:10.1021/jm401040b
(2013)
The modification of ArSCH₂(3,5-Me₂Pz) (Ar = phenyl or 2-pyridyl, Pz = pyrazol-1-yl) by organotin group and related reactions

Doi:10.1016/j.jorganchem.2010.06.006
(2010)

Article Doi