Total synthesis of (-)-virginiamycin M2

DOI: 10.1002/anie.201002220

Source and publish data:

Angewandte Chemie - International Edition p. 6165 - 6168 (2010)

Update date:2022-08-04

Topics:

Authors:

Wu, Jie Wu, Jie

Panek, James S.

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Article abstract of DOI:10.1002/anie.201002220

Has a nice ring to it: A concise and modular total synthesis of the naturally occurring antibiotic virginiamycin M2 is described. A Barbier-type cyclization was used to close the 23-membered macrocycle and deliver virginiamycin M2 in 19 steps from a chiral organosilane.

Full text of DOI:10.1002/anie.201002220

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