Thienotriazolodiazepines as platelet-activating factor antagonists. Steric limitations for the substituent in position 2

DOI: 10.1021/jm00108a031

Source and publish data:

Journal of Medicinal Chemistry p. 1440 - 1446 (1991)

Update date:2022-07-29

Topics: Substituent

Authors:

Walser Walser

Flynn Flynn

Mason Mason

Crowley Crowley

Maresca Maresca

O'Donnell

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Article abstract of DOI:10.1021/jm00108a031

The preparations of thienotriazolodiazepines bearing a substituted ethynyl group at the 2-position, and the corresponding cis-olefins and fully saturated analogues are described. The compounds were evaluated as potential antagonists of platelet-activating

Full text of DOI:10.1021/jm00108a031

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Product name:4-(2-Chlorophenyl)-2-ethynyl-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo [4,3-a][1,4]diazepine

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