1,3-Dipolar Cycloaddition of 1-Methyl-3-oxidopyridinium and Sulfonylethenes. A Synthesis of 2-Tropanols and Monofluorinated 2-Tropanol

DOI: 10.1246/cl.1989.593

Source and publish data:

Chemistry Letters p. 593 - 596 (1989)

Update date:2022-08-05

Topics:

Authors:

Takahashi, Tamiko

Hagi, Toru

Kitano, Kazuyoshi

Takeuchi, Yoshio

Koizumi, Toru

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Article abstract of DOI:10.1246/cl.1989.593

2α- and 2β-Tropanols were synthesized by 1,3-dipolar cycloaddition of phenyl vinyl sulfone and 1-methyl-3-oxidopyridinium regio- and stereoselectively.The method was extended to a preparation of 6α-fluoro-2β-tropanol from 1-(benzenesulfonyl)-1-fluoroethene.

Full text of DOI:10.1246/cl.1989.593

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