Tetrahedron Letters p. 9259 - 9262 (1996)
Update date:2022-08-02
Topics:
Paz, Manuel M.
Correa, Juan F.
Cabeza, M. Isabel
Sardina, F. Javier
An efficient (21% overall yield), enantio- and diastereoselective, 11-step synthesis of (1S,2R)-imidazoleglycerol has been developed. The key steps are the stereoselective hydroxylation of an acyloxazolidinone enolate, the alkylation of a thioester with (MOMOCH2)2CuLi and the stereodivergent reduction of the resulting ketone. The scope of the reaction of the enolate derived from 10 with heteroatom electrophiles has been studied.
View MoreChongqing Rong＆Quan Pharmaceutical Technology Co. , Ltd.
Contact:86-023-65268721
Address:No. 7, Manshanhong Village, Pingdingshan, Shapingba District, Chongqing Province, China
NingBO Hong Xiang Biochem.Co.Ltd
website:http://www.hxbiochem.com
Contact:0574-66003444
Address:Ning Bo Bei Lun
Changzhou Welton Chemical Co., Ltd,
Contact:0086-519-85910828,85920537,85912897
Address:No.8 Jinlong Road, Binjiang Park, Changzhou, Jiangsu, China.
Taizhou Elitechemie MediPharma Technology Co.,Ltd.
Contact:+86-523-86810021
Address:Building G14,NO.1 Avenue,China Medical City, Taizhou, Jiangsu,China
Doi:10.1016/j.tetlet.2010.09.041
(2010)Doi:10.1002/cmdc.201000297
(2010)Doi:10.1021/jo101519t
(2010)Doi:10.1016/j.bmcl.2018.09.033
(2018)Doi:10.1021/jo101640z
(2010)Doi:10.1016/j.tet.2010.09.032
(2010)
