Enzymatic Peptide Synthesis by the Coupling of (Z)-α-Dehydroglutamate with L-α-Amino Acids Using Papain

Article abstract of DOI:10.1246/cl.1989.747

Enzymatic coupling of N-protected α,γ-dimethyl α-dehydroglutamate with L-α-leucine amide using papain at pH 8.0 was first achieved to give α-dehydroglutamylleucine derivatives.