Asymmetric Synthesis of (1-Aminoalkyl)phosphonic Acids via Asymmetric Aldol Reaction of (Isocyanomethyl)phosphonates Catalyzed by a Chiral Ferrocenylphosphine-Gold(I) Complex

Article abstract of DOI:10.1016/S0040-4039(00)99660-6

Reaction of aldehydes (R¹CHO: R¹ = Ph, i-Pr, 3,4-OCH2O-C6H3) with (isocyanomethyl)phosphonates (CNCH2P(O)(OR²)2: R² = Et, Ph) in the presence of 1 molpercent of a chiral ferrocenylphosphine-gold(I) catalyst gave