On pyrrolidine derivatives I. An efficient synthesis of 3-substituted (2S,5S)-pyrrolidine-2,5-dicarboxylic acids

Article abstract of DOI:10.1002/jhet.5570260322

(2S,5S)-3-Alkylpyrrolidine-2,5-dicarboxylic acid derivatives I were stereoselectively synthesized by means of an efficient method starting from L-aspartic acid. (1) Dieckmann reaction of 4-benzyl l-t-butyl N-t-butyl-oxycarbonyl-N-ethoxycarbonylmethyl-L-as