3-AMINO-2H-AZIRINES IN THE SYNTHESIS OF PEPTIDES: TETRAPEPTIDES WITH α,α-DISUBSTITUTED α-AMINO ACIDS

Article abstract of DOI:10.1016/S0040-4020(01)80127-7

3-Amino-2,2-dialkyl-2H-azirines 1 are synthons for α,α-disubstituted α-amino acids.Tetrapeptides 15, containing two such amino acids, were synthesized in high yield by application of the "azirine/oxazolone-method".In this versatile approach for the incorp