Synthesis p. 493 - 496 (1989)
Update date:2022-09-26
Enders, Dieter
Bockstiegel, Bernhard
The lithiated SAMP-hydrazone (S)-3 <(S)-1-(2,2-dimethyl-1,3-dioxan-5-ylideneamino)-2-methoxymethylpyrrolidine> is used as a chiral 1,3-dihydroxyacetone-enolate equivalent C in overall enantioselective α-alkylations leading to 4-alkyl-2,2-dimethyl-1,3-dioxan-5-ones (S)-5a-i in good overall chemical yields and of high enantiomeric purity (ee = 88 - >/= 93percent.
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