Antitumor agents. V. Synthesis and antileukemic activity of E-ring-modified (RS)-camptothecin analogues

DOI: 10.1248/cpb.40.683

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 683 - 688 (1992)

Update date:2022-07-31

Topics:

Authors:

Ejima Ejima

Terasawa

Sugimori

Ohsuki Ohsuki

Matsumoto

Kawato Kawato

Yasuoka Yasuoka

Tagawa Tagawa

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Article abstract of DOI:10.1248/cpb.40.683

Several E-ring-modified analogues of (RS)-camptothecin were synthesized by total synthesis via Friedlander condensation and evaluated for cytotoxicity and antitumor activity against P388 mouse leukemia cells. Among them, (RS)-20-deoxyamino-7-ethyl-10-meth

Full text of DOI:10.1248/cpb.40.683

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