3-Hydroxy-3-methylglutaryl-coenzyme A Reductase Inhibitors. 7. Modification of the Hexahydronaphthalene Moiety of Simvastanin: 5-Oxygenated and 5-Oxa Derivatives

DOI: 10.1021/jm00112a027

Source and publish data:

Journal of Medicinal Chemistry p. 2489 - 2495 (1991)

Update date:2022-07-31

Topics:

Authors:

Duggan, Mark E.

Alberts, Alfred W.

Bostedor, Rick

Chao, Yu-sheng

Germershausen, John I.

et al. et al.

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Article abstract of DOI:10.1021/jm00112a027

Modification of the hexahydronaphthalene ring 5-position in simvastatin 2a via oxygenation and oxa replacement afforded two series of derivatives which were evaluated in vitro for inhibition of 3-hydroxy-3-methylglutaryl-coenzyme.A reductase and acutely i

Full text of DOI:10.1021/jm00112a027

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