3-Hydroxy-3-methylglutaryl-coenzyme A Reductase Inhibitors. 7. Modification of the Hexahydronaphthalene Moiety of Simvastanin: 5-Oxygenated and 5-Oxa Derivatives

DOI: 10.1021/jm00112a027

Source and publish data:

Journal of Medicinal Chemistry p. 2489 - 2495 (1991)

Update date:2022-07-31

Topics:

Authors:

Duggan, Mark E.

Alberts, Alfred W.

Bostedor, Rick

Chao, Yu-sheng

Germershausen, John I.

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00112a027

Modification of the hexahydronaphthalene ring 5-position in simvastatin 2a via oxygenation and oxa replacement afforded two series of derivatives which were evaluated in vitro for inhibition of 3-hydroxy-3-methylglutaryl-coenzyme.A reductase and acutely i

Full text of DOI:10.1021/jm00112a027

Products guided by the article

Product name:6(R)-<2-<6(R)-<1(S)-<(2,2-dimethylbutyryl)oxy>-4-hydroxy-3(R)-methylbutyl>-2(S)-methyl-5(R)-hydroxycyclohexyl-1(S)>ethyl>-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one

Cas No:126359-47-5

R&D Labs maybe for 126359-47-5

Sdow

website:http://www.sdowchem.com

Contact:86-135-2193 7483

Address:8-106 taiyue building
Zhengzhou Xinlian Chemical Tech Co. ,Ltd

Contact:0371-65771781 021-52042910

Address:H Part, Building I, No. 700 Gonglu Road, Pudong New Area, Shanghai
WUXI HONOR SHINE CHEMICAL CO.,LTD

Contact:+86-510-83593312

Address:No.1699 Huishan avenue,Huishan district,Wuxi ,Jiangsu,China,214177.(Wuxi Huishan Ecomonic Develop Zone )
Hisyntech Corporation Limited

Contact:0086-22-23410962

Address:17-201, Ningfuli, Shuishanggongyuandong road,Nankai district, Tianjin, China
Santow Laboratory Limited

Contact:+86-371-55981030

Address:Room 1571, Macalline Soho, No.1, Shangdu Road, Zhengzhou, Henan

Relevant to this article

Synthesis and reactivity of o-benzylphosphino- and o-α- methylbenzyl(N, N-dimethyl)amine-boranes

Doi:10.1021/ic102044z
(2011)
aminoalkylbenzotriazoles: Reagents for the aminoalkylation of electron rich heterocycles

Doi:10.1016/S0040-4020(01)81590-8
(1992)
NITROAZINES. 10. ADDITION OF POLYATOMIC PHENOLS TO 6-NITROAZOLO<1,5-a>PYRIMIDINES

Doi:10.1007/BF00470028
(1989)
Kinetic Resolution Driven Diastereo- and Enantioselective Synthesis of cis-β-Heteroaryl Amino Cycloalkanols by Ruthenium-Catalyzed Asymmetric Transfer Hydrogenation

Doi:10.1021/acs.orglett.6b03334
(2016)
Enantioselective synthesis of α-alkyl,α-vinyl amino acids via [2,3]-sigmatropic rearrangement of selenimides

Doi:10.1021/ol1030926
(2011)
Room-temperature synthesis of soluble, fluorescent carbon nanoparticles from organogel precursors

Doi:10.1039/c2cc35087d
(2012)

Article Doi