Synthesis p. 688 - 690 (1989)
Update date:2022-08-05
Topics:
Choudhary, Anil
Baumstark, Alfons L.
A general method for the facile dimethylation of 1,3-diketones is presented.The method involves the use of readily available, inexpensive reagents and is carried out under mild conditions.Monomethylation may be carried out by slight modification (simplification) of the procedure.Several examples are presented which show that the method is applicable to alkylations with primary halides as well.Isolated yields for monoalkylation are approximately 95percent while those for dialkylation are ca. 90percent.Alkylation is taking place by the reaction of the enolates of 1,3-diketones
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Doi:10.1016/j.bmcl.2010.10.141
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(2011)Doi:10.1002/aoc.1720
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