Synthesis and biological activity of open-chain analogues of 5,6,7,8- tetrahydrofolic acid-potential antitumor agents

DOI: 10.1021/jm00086a008

Source and publish data:

Journal of Medicinal Chemistry p. 1399 - 1410 (1992)

Update date:2022-08-03

Topics: Synthesis Antitumor agents Biological Activity

Authors:

Bigham Bigham

Hodson Hodson

Mallory Mallory

Wilson Wilson

Duch Duch

Smith Smith

Ferone Ferone

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Article abstract of DOI:10.1021/jm00086a008

This study describes the synthesis and in vitro antitumor activity of inhibitors of purine de novo biosynthesis that are analogues of N-[4-[[3- (2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl]amino]benzoyl-L-glutamic acid (5-DACTHF). Benzene ring subs

Full text of DOI:10.1021/jm00086a008

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