Tetrahedron p. 377 - 392 (1992)
Update date:2022-08-05
Topics:
Fukuyama, Yoshiyasu
Otoshi, Yukio
Miyoshi, Kumi
Nakamura, Kazuhiko
Kodama, Mitsuaki
et al.
Novel sesquiterpene-neolignans, eudesobovatols A (1) and B (2), eudesmagnolol (3), eudeshonokiols A (4) and B (5), clovanemagnolol (6), and caryolanemagnolol (7), have been isolated from the bark of Magnolia obovata.Their structures were elucidated to be sesquiterpenes (eudesmol, 4,4,8-trimethyltricyclo<6.3.1.02,5>dodecane-1,9-diol, and clovanediol) combined through ether bond with neolignans such as obovatol, honokiol, and magnolol on the basis of spectral data, degradation, and/or synthesis.Compounds 1, 6, and 7 were found to exhibit interesting neurotrophic activity on a neuronal cell culture system derived from fetal rat hemisphere.
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(2013)
