1,4-Bis(3-oxo-2,3-dihydropyridazin-6-yl)benzene Analogues: Potent Phosphodiesterase Inhibitors and Inodilators

DOI: 10.1021/jm00168a031

Source and publish data:

Journal of Medicinal Chemistry p. 1735 - 1741 (1990)

Update date:2022-08-05

Topics:

Authors:

Coates, William J.

Prain, H. Douglas

Reeves, Martin L.

Warrington, Brian H.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00168a031

1,4-Bis(3-oxo-2,3-dihydropyridazin-6-yl)benzene and a series of related bis(azinone) compounds were synthesized.These novel compounds were evaluated for inhibition of the low K_m, cAMP-selective, cGMP-inhibited phosphodiesterase (PDE III) derive

Full text of DOI:10.1021/jm00168a031

Products guided by the article

Product name:C₂₀H₁₄N₄O₂

Cas No:126725-01-7

R&D Labs maybe for 126725-01-7

Shanghai Harvest Chemical Ind. Co., Ltd.

Contact:021-51385350

Address:ROOM 806-807, AI LI CHEN BUILDING, No.333 JINGXIANG ROAD, PUDONG DISTRICT, 201206, SHANGHAI
Xiamen Hisunny Chemical Co.,Ltd

website:http://www.hisunnychem.com

Contact:+86-592-3327115

Address:Unit 603,No.879,Xiahe Road,Meixin Building,Xiamen,China
Shanghai Yuantai Chemical Products Co., Ltd

Contact:021--66129803

Address:Chengyin Road,Shanghai,China
Anhui Hope-Chem Co., Ltd.

Contact:86-551-63540590

Address:No 1388 Furong Rd., Hefei, Anhui, China
Chengda Pharmaceuticals Co., Ltd.

Contact:+86-573-84601188

Address:hengshan Road 5# in Jiashan, zhejiang

Relevant to this article

AN EFFICIENT THIOGLYCOSIDE-MEDIATED FORMATION OF α-GLYCOSIDIC LINKAGES PROMOTED BY IODONIUM DICOLLIDINE PERCHLORATE

Doi:10.1016/S0040-4039(00)94391-0
(1990)
Peroxides as plant constituents, VII: Formation of the sesquiterpeneperoxide nardosinone from an aristolane precursor

Doi:10.1002/ardp.19903230308
(1990)
Synthesis of α,β-Unsaturated Thiocarboxylic Acid S-Esters via Horner-Emmons Olefination

Doi:10.1055/s-1990-26784
(1990)
Structure-Activity Relationships of 8-Cycloalkyl-1,3-dipropylxanthines as Antagonists of Adenosine Receptors

Doi:10.1021/jm00169a012
(1990)
DONOR SUBSTITUTED SULFONYL CARBENES - 1. METHOXY ARYLSULFONYL CARBENES

Doi:10.1016/S0040-4020(01)89137-7
(1989)
Synthesis, spectroscopic characterization and preliminary antimicrobial studies of Mn(II) and Cu(II) complexes of two thiolates; S,S'-(2,6- diaminopyridine-3,5-diyl) dibenzenecarbothioate (DBCT) and S-benzyl benzenecarbothioate (BBCT)

Doi:10.1155/2011/214870
(2011)

Article Doi