1,4-Bis(3-oxo-2,3-dihydropyridazin-6-yl)benzene Analogues: Potent Phosphodiesterase Inhibitors and Inodilators

DOI: 10.1021/jm00168a031

Source and publish data:

Journal of Medicinal Chemistry p. 1735 - 1741 (1990)

Update date:2022-08-05

Topics:

Authors:

Coates, William J.

Prain, H. Douglas

Reeves, Martin L.

Warrington, Brian H.

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Article abstract of DOI:10.1021/jm00168a031

1,4-Bis(3-oxo-2,3-dihydropyridazin-6-yl)benzene and a series of related bis(azinone) compounds were synthesized.These novel compounds were evaluated for inhibition of the low K_m, cAMP-selective, cGMP-inhibited phosphodiesterase (PDE III) derive

Full text of DOI:10.1021/jm00168a031

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