Structure-Activity Relationships of 8-Cycloalkyl-1,3-dipropylxanthines as Antagonists of Adenosine Receptors

Article abstract of DOI:10.1021/jm00169a012

8-Substituted xanthines currently represent the most potent class of adenosine-receptor antagonists.A series of 8-substituted 1,3-dipropylxanthines was prepared and their potency as antagonists of A1 and A2 adenosine receptors of human platelets and rat a