Stereoselective α-Methylation of N-Methyl Benzylamine via a Combination of Chromium Tricarbonyl and Chiral Formamidine Methodologies.

DOI: 10.1016/S0040-4039(01)93512-9

Source and publish data:

Tetrahedron Letters p. 5945 - 5948 (1989)

Update date:2022-08-05

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Authors:

Albert, Joan

Davies, Stephen G.

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Article abstract of DOI:10.1016/S0040-4039(01)93512-9

Whereas carbanions of formamidines derived from N-methyl benzylamine and L-valinol or L-leucinol undergo electrophilic benzylic methylation with poor stereoselectivities (d.e. 17-26percent), enhanced stereoselectivities (d.e. 74-84percent) are observed for the corresponding chromium tricarbonyl complexes.

Full text of DOI:10.1016/S0040-4039(01)93512-9

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