
Organic and Biomolecular Chemistry p. 444 - 451 (2018)
Update date:2022-08-05
Topics:
Paul, Sayantan
Bhattacharya, Asish K.
An efficient, transition-metal free and direct C-arylation of 3-hydroxychromone moieties in the presence of a base, air as an oxidant and arylhydrazines as arylating agents to furnish highly biologically active flavonols or 3-hydroxyflavones has been developed. We have further extended our methodology for the C-arylation of the 5-hydroxy pyran-4-one moiety. The role of the free hydroxyl group towards C-arylation has been delineated.
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