High-yielding synthesis of 1-isoindolinone derivatives via palladium-catalysed cycloaminocarbonylation

Article abstract of DOI:10.1016/j.tet.2010.11.099

1-Isoindolinone derivatives were synthesised in high yields (up to 89%) by using 2-iodobenzyl bromide and 2-iodobenzylamine as bifunctional substrates in palladium-catalysed carbonylation. Depending on the N-nucleophiles, two types of compounds were synth