SOLID PHASE SYNTHESIS OF OLIGONUCLEOTIDES CONTAINING 3'-THIOTHYMIDINE

DOI: 10.1016/S0040-4039(01)80776-0

Source and publish data:

Tetrahedron Letters p. 4693 - 4696 (1989)

Update date:2022-09-26

Topics:

Authors:

Cosstick, Richard

Vyle, Joseph S.

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Article abstract of DOI:10.1016/S0040-4039(01)80776-0

A 5'-O-monomethoxytritylthymidine-3'-S-thiophosphoramidite (3) has been used to prepare oligodeoxynucleotides containing 3'-thiothymidine on a solid phase support.The intermediate thiophosphites are most efficiently oxidised using tetrabutylammonium periodate.

Full text of DOI:10.1016/S0040-4039(01)80776-0

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