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14 General procedure for the metal-free reductive coupling reaction
of tosylhydrazones 1 with thiols 2: a mixture of tosylhydrazone 1
(0.3 mmol), thiol 2 (0.6 mmol, 2.0 equiv.) and K2CO3 (0.9 mmol,
3.0 equiv.) in dioxane (3.0 mL) is stirred at 110 ◦C for 24 h under
N2. After completion of the reaction, as indicated by TLC, the mixture
is cooled to room temperature. After adding ethyl acetate (10 mL), the
organic phase is washed with saturated brine, dried with MgSO4 and
concentrated under a vacuum. The residue is then purified by flash
chromatography on silica gel to afford product 3 (for details, please see
the ESI†).
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