Electrophilic Olefin Heterocyclization in Organic Synthesis. Highly Stereoselective Synthesis of Trans 3,5-Disubstituted Pyrrolidin-2-ones by Iodolactamization via Homoallylic Asymmetric Induction

DOI: 10.1021/jo00299a019

Source and publish data:

Journal of Organic Chemistry p. 3792 - 3797 (1990)

Update date:2022-08-04

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Authors:

Takahata, Hiroki

Takamatsu, Tamotsu

Chen, Yin-Shan

Ohkubo, Naoki

Yamazaki, Takao

et al. et al.

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Article abstract of DOI:10.1021/jo00299a019

α-Substituted γ,δ-unsaturated thioimidates 19-24, prepared by methylation of the corresponding thioamides 13-18, undergo iodine-induced lactamization to provide the 3,5-disubstituted pyrrolidin-2-ones 25a,b-30a,b.High 1,3-asymmetric induction by the homoa

Full text of DOI:10.1021/jo00299a019

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