Bioorganic and Medicinal Chemistry Letters p. 1741 - 1743 (2011)
Update date:2022-08-02
Topics:
Semko, Christopher M.
Chen, Linda
Dressen, Darren B.
Dreyer, Mark L.
Dunn, Whitney
Farouz, Francine S.
Freedman, Stephen B.
Holsztynska, Elizabeth J.
Jefferies, Michael
Konradi, Andrei W.
Liao, Anna
Lugar, Judevin
Mutter, Linda
Pleiss, Michael A.
Quinn, Kevin P.
Thompson, Thomas
Thorsett, Eugene D.
Vandevert, Christopher
Xu, Ying-Zi
Yednock, Ted A.
A series of N-(pyrimidin-4-yl)-phenylalanine VLA-4 antagonists is described. Optimization of substituents at the 2 and 5 positions of the pyrimidine ring gave 14, a very potent VLA-4 inhibitor which is orally active in a sheep asthma model.
View MoreValiant Fine Chemicals Co., Ltd.
Contact:+86 535 6101878/6374484
Address:11 Wuzhishan Rd.,YTETDZ,Yantai,264006,Shandong,China
Yancheng Smiling Imp & Exp Co., Ltd.
Contact:+86-515-83173586
Address:Rm1207, BLD#03, Phoenix Plaza, Juheng Road, Yancheng, Jiangsu, P.R. China
Goldwills Pharmaceuticals Co., Ltd.
Contact:0916-2237889 13991621155
Address:North Suburb of Hanzhong city, Shaanxi Province
SHANDONG CREDAGRI CHEMICAL CO., LTD.
Contact:+86-531-88872050
Address:ROOM 601A, BUILDING 2, SHUNTAI SQUARE, NO. 2000 SHUNHUA ROAD, HI-TECH DEVELOPMENT ZONE, JINAN, CHINA.
ZHEJIANG JIANYE CHEMICAL CO.,LTD.
Contact:86-571-64149273,64149234
Address:No. 48, Fuxi Road, Meicheng Town
Doi:10.1016/S0040-4039(01)93489-6
(1989)Doi:10.1016/S0040-4039(00)94647-1
(1990)Doi:10.1016/S0008-6215(98)00271-7
(1998)Doi:10.1246/bcsj.63.652
(1990)Doi:10.1021/jo991350a
(2000)Doi:10.1021/jo500481j
(2014)