Tetrahedron Letters p. 859 - 862 (1990)
Update date:2022-08-02
Topics:
Langhals, Elke
Langhals, Heinz
A mixture of solid KOH in dimethyl sulfoxide has a strong basicity, but only a low nucleophilicity and is used for α-methylation of ketones.With this simple and inexpensive reagent complete methylation with yields up to 90percent can be achieved.
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