Journal of Organic Chemistry p. 2786 - 2797 (1990)
Update date:2022-09-26
Topics:
Jones, A. Brian
Villalobos, Annabella
Linde, Robert G.
Danishefsky, Samuel J.
The coupling of the previously described subunits 2, 3, and 4 is described.The C28-C27 E-double bond is fashioned from a sulfurane induced dehydration of alcohol 11.The C19-C20 E-double bond was constructed via a modified Julia process culminating in a reductive elimination of a vicinal trifluoroacetoxy sulfone (see 22 -> 23 -> 24 and 25).The synthesis of intermediates anticipating potential macrolactonization are also described.
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(2011)Doi:10.1016/S0040-4020(98)01173-9
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(1990)Doi:10.1039/c39900000328
(1990)Doi:10.1016/0008-6215(89)85089-X
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