The use of crown ethers in peptide chemistry: Part 3 synthesis of an enkephalin derivative using 18-crown-6 as a non-covalent amino protecting group

Article abstract of DOI:10.1016/S0040-4039(00)94565-9

The efficacy of amino acid protection with crown ethers is demonstrated by the solution synthesis of an enkephalin pentapeptide derivative. Extraction of the organic phase with a KCl solution after each coupling steps is used for the deprotection of the peptide intermediate.