European Journal of Medicinal Chemistry p. 61 - 66 (1990)
Update date:2022-08-05
Topics:
Lafont
Cave
Menager
Miocque
Primidone is metabolized either into phenylethylmalondiamide or phenobarbital. 2-Hydroxyprimidone was synthesized and tested as a potential intermediate common to these two biodegradation pathways in dogs as well as in vitro. On the other hand, the mechanism of the formation of α-phenyl-γ-butyrolactone during intoxication was investigated and the role of precursor played by the phenobarbital generated in vivo was shown.
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(1968)
