ENZYMATIC KINETIC RESOLUTION OF CYANOHYDRIN ACETATES AND ITS APPLICATION TO THE SYNTHESIS OF (S)-(-)-FRONTALIN

DOI: 10.1016/S0040-4020(01)89493-X

Source and publish data:

Tetrahedron p. 5469 - 5476 (1989)

Update date:2022-07-29

Topics:

Authors:

Ohta, Hiromichi

Kimura, Yoichi

Sugano, Yasushi

Sugai, Takeshi

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Article abstract of DOI:10.1016/S0040-4020(01)89493-X

Kinetic resolution of racemic 1-cyano-1-methylalkyl and alkenyl acetates has been achieved on incubation with Pichia miso IAM 4682, which hydrolyzed selectively the (R)-enantiomer, leving behind the (S)-enantiomer intact.The chiral 1-cyano-1-methyl-5-hexenyl acetate thus obtained was converted to (S)-frontalin via unsaturated diol.

Full text of DOI:10.1016/S0040-4020(01)89493-X

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