Benzotriazole-assisted synthesis of novel mannich bases from ketones and diverse aldehydes

Article abstract of DOI:10.1016/S0040-4020(01)81378-8

A wide variety of β-amino ketones are prepared in moderate to good yields by the reaction of the lithium enolates of cyclohexanone, acetophenone, α-tetralone and camphor with the readily available adducts from an aldehyde or ketone, an amine and benzotriazole. Some diastereoselectivity is observed when the benzotriazole adduct is derived from benzaldehyde.