X=Y-ZH SYSTEMS AS POTENTIAL 1,3-DIPOLES. PART 25. INTRAMOLECULAR CYCLOADDITION REACTIONS OF PYRIDOXAL IMINES OF Ε-ALKENYL Α-AMINO ESTERS. A POSSIBLE NEW APPROACH TO PYRIDOXAL ENZYME INHIBITION

Article abstract of DOI:10.1016/S0040-4020(01)89219-X

Pyridoxal imines of ε-alkenyl α-amino esters undergo an intramolecular cycloaddition, via an intermediate azomethine ylide, on keeping at room temperature for a prolonged period of time.The implications of this observation for the design of inhibitors of